Oxidative stress in diabetic neuropathy: source of reactive oxygen species
نویسندگان
چکیده
منابع مشابه
Oxidative stress and reactive oxygen species.
This article discusses different aspects concerning classification/nomenclature, biochemical properties and pathophysiological roles of reactive oxygen species (ROS) which are pivotal to interpret the concept of oxidative stress. In vitro studies in both the prokaryotes and eukaryotes clearly demonstrate that exogenous or constitutive and inducible endogenous sources of ROS together with cofact...
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This review examines the role of oxidative stress in damage to cells of the trabecular meshwork and associated impaired aqueous drainage as well as damage to retinal ganglion cells and associated visual field losses. Consideration is given to the interaction between vascular and mechanical explanations for pathological changes in glaucoma. For example, elevated intraocular pressure (IOP) forces...
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Reactive oxygen species (ROS) include both free radicals and non-radical compounds. ESR spectroscopy, especially employing spin traps, is the unique technique allowing for detection, identification and quantification of free radicals in vitro and their imaging in vivo. However, the sensitivity of this technique is limited and essays based on the use of more sensitive fluorogenic and luminogenic...
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Several reactive oxygen species (ROS) are continuously produced in plants as byproducts of aerobic metabolism. Depending on the nature of the ROS species, some are highly toxic and rapidly detoxified by various cellular enzymatic and nonenzymatic mechanisms. Whereas plants are surfeited with mechanisms to combat increased ROS levels during abiotic stress conditions, in other circumstances plant...
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Diabetic neuropathy (DN) is a widespread disabling disorder comprising peripheral nerves' damage. DN develops on a background of hyperglycemia and an entangled metabolic imbalance, mainly oxidative stress. The majority of related pathways like polyol, advanced glycation end products, poly-ADP-ribose polymerase, hexosamine, and protein kinase c all originated from initial oxidative stress. To da...
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ژورنال
عنوان ژورنال: Endocrinology Studies
سال: 2012
ISSN: 2038-9523,2038-9515
DOI: 10.4081/es.2012.e6